Struggling to make prevalence statements that pass regulatory muster? In this concise lesson you’ll learn to draft regulator‑ready prevalence and orphan‑subset paragraphs that tie every number to a clear case definition, denominator, numerator, source, method, and uncertainty statement. You’ll get a five‑part writing template, annotated real‑doc examples, and short exercises to test your wording—designed for executive reviewers who need precise, non‑promotional, FDA/EMA‑ready text.